- Title
- Targeted therapeutics for severe refractory asthma: Monoclonal antibodies
- Creator
- Grainge, Christopher L.; Maltby, Steven; Gibson, Peter G.; Wark, Peter A.B.; McDonald, Vanessa M.
- Relation
- Expert Review of Clinical Pharmacology Vol. 9, Issue 7, p. 927-941
- Publisher Link
- http://dx.doi.org/10.1586/17512433.2016.1172208
- Publisher
- Taylor & Francis
- Resource Type
- journal article
- Date
- 2016
- Description
- Severe asthma is a complex multifactorial disease that requires specialist multidisciplinary input for optimal clinical outcomes. Following multidimensional assessment for optimisation of current therapy, self-management skills and comorbidities, all patients should be accurately phenotyped. Only after this assessment has been completed should new monoclonal antibody therapies be considered. In this review, we summarise the new antibody approaches targeting identified pathological pathways in severe refractory asthma.
- Subject
- severe asthma; treatment-refractory asthma; monoclonal; phenotype; biomarker; targeted therapy; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1479494
- Identifier
- uon:50315
- Identifier
- ISSN:1751-2433
- Language
- eng
- Reviewed
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